Folic acid and orofacial clefts: a review of the evidence

Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage.

Key research findings relative to the question of whether maternal use of folic acid before and during pregnancy reduces the chance that offspring will be born with a congenital heart defect or an orofacial cleft are reviewed in this paper. Observational studies in general support an association between maternal use of multivitamins containing folic acid and a reduction in the occurrence of con...

Dose-dependent effect of folic acid on the prevention of orofacial clefts.

OBJECTIVE In 1982, Tolarova(4) found a reduction in the recurrence rate of isolated cleft lip (CL) with or without cleft palate (CP; CL +/- CP) after periconceptional supplementation with a multivitamin including a very high dose (10 mg) of folic acid. The Hungarian randomized, double-blind, controlled trial of periconceptional supplementation with a multivitamin including a physiologic dose (....

Epigenetics and Orofacial Clefts: A Brief Introduction.

Prenatal detection of orofacial clefts

Orofacial clefts are one of the most common congenital anomalies. The incidence is approximately 1 : 500 to 1 : 550 births [1]. The group of orofacial anomalies is heterogeneous. It comprises “typical” orofacial clefts ((cleft lip (CL), cleft lip and cleft palate (CLP) and cleft palate only (CP)) and “atypical” clefts (median, transversal, oblique and other Tessier’s types of facial clefts)[1]....

[Prenatal detection of orofacial clefts].

Orofacial clefts are one of the most common congenital anomalies. The incidence is approximately 1 : 500 to 1 : 550 births [1]. The group of orofacial anomalies is heterogeneous. It comprises “typical” orofacial clefts ((cleft lip (CL), cleft lip and cleft palate (CLP) and cleft palate only (CP)) and “atypical” clefts (median, transversal, oblique and other Tessier’s types of facial clefts)[1]....